马英新博士，中国科学院深圳先进技术研究院，研究员，博士生导师。国家自然科学基金优秀青年项目获得者，国家重点研发计划合成生物学专项青年项目首席科学家。于北京师范大学获得化学学士学位，北京化工大学获得硕士和博士学位。在J Am Chem Soc、Nat Commun、ACS Nano、Sci China Life Sci、Anal Chem、ACS Appl Mater Inter等杂志共发表论文60篇。申请国家发明专利26项，授权15项。主持国家自然科学基金优秀青年项目，国家重点研发计划合成生物学专项青年科学家项目，广东省自然科学基金杰出青年科学基金，深圳市优秀科技创新人才培养项目等10项基金。入选中国科学院“青年创新促进会”。实验室主要研究方向聚焦于合成生物学使能技术开发，包括：基因组的操作与改造；单颗粒/单分子示踪；合成生物传感系统。

基因组的操作与改造

1.Wen Yin#, Leyao Li#, Yang Yang, Yuxin Yang, Ruijing Liang, Lixin Ma, Junbiao Dai, Guobin Mao*, Yingxin Ma*. Ultra-Sensitive Detection of the SARS-CoV-2 Nucleocapsid Protein via a Clustered Regularly Interspaced Short Palindromic Repeat/Cas12a-Mediated Immunoassay. ACS Sensors 2024, 9, 3150-3157. (SI Cover Story)
2.Guobin Mao*, Xing Luo, Silu Ye, Xun Wang, Jin He, Jilie Kong, Junbiao Dai, Wen Yin*, Yingxin Ma*. Fluorescence and Colorimetric Analysis of African Swine Fever Virus Based on the RPA-Assisted CRISPR/Cas12a Strategy. Analytical Chemistry 2023, 95, 8063-8069. (SI Cover Story)
3.Yingxin Ma#*, Guobin Mao#, Weishan Yang#, Guoqiang Wu, Guoqiang Li, Xiaoying Li, Xin Lin, Junnan Lu, Shijun Zhao, Wei Zhao, Junbiao Dai*, Xian-En Zhang*. Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system. Science China Life Science 2022, 65, 1894-1897.
4.Yingxin Ma#, Guobin Mao#, Weiren Huang#, Guoqiang Wu, Wen Yin, Xinghu Ji, Zishi Deng, Zhiming Cai, Xian-En Zhang, Zhike He*, Zongqiang Cui*. Quantum Dot Nanobeacons for Single RNA Labeling and Imaging. Journal of the American Chemical Society 2019, 141, 13454-13458. (SI Cover Story) 
5.Yingxin Ma#, Mingxiu Wang#, Wei Li, Zhiping Zhang, Xiaowei Zhang, Tianwei Tan, Xian-En Zhang*, Zongqiang   Cui*. Live cell imaging of single genomic loci with quantum dot-labeled TALEs. Nature Communications 2017, 8, 15318.

在研项目                                                                     
1.    国家重点研发计划合成生物学专项（青年科学家项目，2021YFA0910900），病原示踪复合标记体系的设计与合成，2021.12-2026.11，500万元，在研，主持。
2.    国家自然科学基金青年科学基金项目（B类）（32222044），单病毒示踪，2023.01-2025.12，200万元，在研，主持。
3.    深圳市发展改革委战略性新兴产业发展专项资金扶持计划（XMHT20251127001），智能基因编辑与基因组合成系统开发，2025.01-2027.12，1000万元，在研，主持。
4.    国家自然科学基金面上项目（32471389），靶向抗病毒分子机器的设计与构建，2025.01-2028.12，50万元，在研，主持。
5.    深圳市基础研究专项（自然科学基金）重点项目（202412023000365），基20240099新发、突发重大传染病病原体及疫情监测和预警体系和技术建设研究，2025.01-2027.12，200万元，在研，主持。
结题项目                                                                     
6.    广东省自然科学基金杰出青年科学基金项目（2018B030306046），HIV-1病毒逆转录的动态过程及分子机制研究，2018.05-2022.04，100万元，已结题，主持。
7.    深圳市优秀科技创新人才培养项目（优秀青年基础研究，RCYX20210609103823046），单病毒示踪，2022.04-2025.04，200万元，已结题，主持。
8.    中国科学院青年创新促进会会员（2021359），2021.01-2024.12，80万元，已结题，主持。
9.    国家自然科学基金青年科学基金项目（C类）（21705110），多功能复合荧光纳米传感器用于HIV病毒的治疗诊断学研究，2018.01-2020.12，24万元，已结题，主持。
10.    中国博士后科学基金会“博士后创新人才支持计划”项目（BX201700161），HIV-1病毒可视化精准检测及早期治疗，2017.06-2019.06，60万元，已结题，主持。
11.    中国博士后科学基金面上资助项目（2017M622860），HIV-1病毒逆转录过程的实时动态可视化研究，2017.06-2019.06，5万元，已结题，主持。
12.    中国科学院深圳先进技术研究院优秀青年创新基金，HIV-1病毒的多重荧光标记及动态示踪，2020.01-2021.12，20万元，已结题，主持。发表论文                                                                     
1.    Guobin Mao#, Wen Yin#, Yeling Yang#, Yuan Zeng, Jie Zhou, Jia-Ao Li, Yanhui Wan*, Wenhua Zhou, Xue-Feng Yu, Junbiao Dai, Yingxin Ma*. Novel Antibiotic-Derived Silicon Dots with Broad-Spectrum Antibacterial Activity and Efficient Wound Healing Promotion. Small 2025, Dec 29:e12500.
2.    Zishi Deng#, Xuhua Mao#, Yeling Yang, Guoqiang Wu, Huan Meng, Jiexin Hou, Xue-Feng Yu, Wenhua Zhou*, Guobin Mao*, Yingxin Ma*. Amplification-free CRISPR/Cas12a biosensor integrating AuNPs-mediated surface plasmon resonance for human papillomavirus detection and genotyping. Biosensors and Bioelectronics 2025, 290, 117960.
3.    Yeling Yang#, Yufei Yang#, Xuhua Mao, Wenhua Zhou, Xue-Feng Yu, Guobin Mao*, Yingxin Ma*. Multiplex microRNA detection for breast cancer precise diagnosis by constructing split crRNA-based amplification-free CRISPR/Cas12a biosensor. Chemical Engineering Journal 2025, 522, 167489.
4.    Chunmin Qiu#, Guoqiang Wu#, Puying Zhao, Junbiao Dai, Qian Luo, Liqing Zhao*, Guobin Mao*, Yingxin Ma*. Intrinsic dual-emitting Si dots for high-precision and broad-range pH detection. Analytica Chimica Acta 2025, 1339, 343637.
5.    Guobin Mao#, Yuan Zeng#, Chunmin Qiu, Guangmiao Ding, Leyao Li, Lixin Ma, Junbiao Dai, Wen Yin*, Yingxin Ma*. Ratiometric fluorescent paper chip for monitoring the freshness of high protein foods. Analytica Chimica Acta 2025, 1334, 343418.
6.    Guobin Mao#, Yuan Zeng#, Guangmiao Ding, Chunmin Qiu, Junbiao Dai, Yanhui Wan*, Yingxin Ma*.  Dual-emission Si dots-based sensing array for identification of metal ions. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2025, 329, 125500.
7.    Wen Yin#, Leyao Li#, Yang Yang, Yuxin Yang, Ruijing Liang, Lixin Ma, Junbiao Dai, Guobin Mao*, Yingxin Ma*. Ultra-Sensitive Detection of the SARS-CoV-2 Nucleocapsid Protein via a Clustered Regularly Interspaced Short Palindromic Repeat/Cas12a-Mediated Immunoassay. ACS Sensors 2024, 9, 3150-3157. (SI Cover Story)
8.    Yao Yu#, Qiaoyu Li#, Wen Shi, Yuxin Yang, Hongpeng He, Junbiao Dai, Guobin Mao*, Yingxin Ma*. Programmable Aptasensor for Regulating CRISPR/Cas12a Activity. ACS Sensors 2024, 9, 244-250. (SI Cover Story)
9.    Guobin Mao, Qiaoyu Li, Ziying Zhang, Wei Huang, Qian Luo, Junbiao Dai, Weiren Huang*, Yingxin Ma*. Analyte-induced hindrance in the RCA-assisted CRISPR/Cas12a system for homogeneous protein assays. Analytica Chimica Acta 2024, 1330, 343294.
10.    Guoqiang Wu#, Qiaoyu Li#, Junbiao Dai, Guobin Mao*, Yingxin Ma*. Design and Application of Biosafe Coronavirus Engineering Systems without Virulence. Viruses 2024, 16, 659.
11.    Yuge Feng, Cong Su, Guobin Mao, Baoting Sun, Yizhi Cai, Junbiao Dai*, Yingxin Ma*. When synthetic biology meets medicine. Life Medicine 2024, 3, lnae010.
12.    Wenfei Yu, Junbiao Dai*, Yingxin Ma*. Recent development on DNA & genome synthesis. Current Opinion in Systems Biology 2024, 37, 100490.
13.    梁颖琪，毛国斌*，戴俊彪，马英新*。单病毒示踪。中国科学：生命科学 2024, 54, 396-408。
14.    Shuangying Jiang, Yingxin Ma, Junbiao Dai*. Synthetic yeast genome project and beyond. The Innovation Life 2024, 2, 100059.
15.    Guiqi Bi#, Shijun Zhao#, Jiawei Yao#, Huan Wang†, Mengkai Zhao, Yuanyuan Sun, Xueren Hou, Fabian B. Haas, Deepti Varshney, Michael Prigge, Stefan A. Rensing, Yuling Jiao, Yingxin Ma, Jianbin Yan*, Junbiao Dai*. Near telomere-to-telomere genome of the model plant Physcomitrium patens. Nature Plants 2024, 10, 327-343.
16.    Lian-Ge Chen#, Tianlong Lan#, Shuo Zhang#, Mengkai Zhao#, Guangyu Luo, Yi Gao, Yuliang Zhang, Qingwei Du, Houze Lu, Bimeng Li, Bingke Jiao, Zhangli Hu, Yingxin Ma, Qiao Zhao, Ying Wang*, Wenfeng Qian*, Junbiao Dai*, Yuling Jiao*. A designer synthetic chromosome fragment functions in moss. Nature Plants 2024, 10, 228-239.
17.    Li Cheng#, Shijun Zhao#, Tianyi Li#, Sha Hou#, Zhouqing Luo, Jinsheng Xu, Wenfei Yu, Shuangying Jiang, Marco Monti, Daniel Schindler, Weimin Zhang, Chunhui Hou, Yingxin Ma, Yizhi Cai, Jef D. Boeke, Junbiao Dai*. Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae. Nature Communications 2024, 15, 770.